5 Benefits of Serrapeptase and What to Know Before Taking
By: Spencer Brooks
- Serrapeptase is an enzyme that comes from silkworms. It dissolves proteins that can accumulate in your body in response to inflammation and injury (especially scarring).
- Serrapeptase has lots of benefits. It thins mucus, which makes it good for clearing your sinuses when you have a cold.
- Serrapeptase is also a strong antimicrobial. It weakens biofilms around antibiotic-resistant bacteria, which can make it a great way to get rid of pathogens.
- You’ll want to avoid taking serrapeptase with certain supplements and medications. Read below for full details about serrapeptase benefits, drug interactions, dosage, and sourcing.
Serrapeptase has loads of benefits. It may also have the coolest origin story of any supplement.
This unusual enzyme comes from Serratia, a bioactive group of bacteria that live inside silkworms. Serratia are essential to the silkworm’s survival. After it weaves a silk cocoon and begins transforming into a moth, it releases Serratia bacteria from its gut. The Serratia produce serrapeptase, an enzyme that eats through protein. The serrapeptase dissolves the silk cocoon, opening it up for the silkmoth to emerge.
Even cooler? Serrapeptase’s protein-dissolving properties can be just as useful in your body — boasting plenty of benefits. You can take serrapeptase to help dissolve scar tissue, fight inflammation, improve your immune response, and decrease pain. Read on to learn about serrapeptase’s benefits, dosage, dangers, drug interactions, and more.
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What is serrapeptase?
Serrapeptase is an enzyme — a compound that influences reactions in your body. Enzymes control the speed at which your body’s processes happen. For example, if you’re lactose-intolerant, it’s because you don’t produce enough of the enzyme lactase. Lactase dramatically speeds up your ability to digest the sugar in milk; without it, the milk sugar breaks down very, very slowly, and you run into digestive trouble. Enzymes are essential to performing at your best.
“We all have an enzyme bank account in our bodies,” explains Matt Gallant, an expert on enzyme biohacking. “Everything from thinking to blinking, enzymes are involved. They’re the catalyst that kickstarts chemical and biochemical reactions in the body.” (listen to Matt’s Bulletproof Radio podcast interview here to learn more about using enzymes to your advantage).
Serrapeptase in particular makes proteins break down much faster. It degrades dense proteins that most other enzymes can’t touch. An example is fibrin, a particularly tough protein that accumulates in scar tissue.
5 serrapeptase benefits you can actually feel
Serrapeptase’s benefits come from its protein-dissolving properties. This makes it a versatile addition to your biohacking toolbox. You can take serrapeptase for a few different reasons:
If you have a cold and your nose is stuffed up, serrapeptase can help (so can the Bulletproof guide to cold and flu hacking). Serrapeptase makes it easier to blow your nose when you’re sick because it breaks down proteins in mucus and makes the mucus thinner.
Kill antibiotic-resistant bacteria
Antibiotics cause massive damage to your gut and mitochondria. They should be your last resort for dealing with an infection. But sometimes antibiotics really are the best course of action, and at those times, serrapeptase benefits you by making antibiotics more effective. It weakens the biofilms around antibiotic-resistant bacteria, making them more susceptible to antibiotics.  Bonus tip: after you take antibiotics, be sure you restore your gut flora to get back on your feet as quickly as possible.
Break down scar tissue
Serrapeptase dissolves fibrin, a particularly tough protein that makes up scar tissue, and emerging research suggests that high doses of serrapeptase may reduce scarring. This guide to removing scars may help you, too.
Serrapeptase dangers and drug interactions
Serrapeptase breaks down proteins in mucus, making it easier to breathe when you have a cold. It also thins out the white blood cell-rich fluid that gathers around wounds, making them easier to drain and easing inflammation.
The pattern there is that serrapeptase makes thick fluids thinner. In the case of a cold or an persistently inflamed injury, that’s great. That said, if you’re already taking medications or supplements that also thin fluid, you should be careful about adding serrapeptase to the mix. Serrapeptase drug interactions and supplement interactions include:
- Fish oil. Fish oil is a mild-to-moderate blood thinner, as is serrapeptase. The two together may make your blood too thin. Fish oil and serrapeptase aren’t necessarily dangerous together, but they can be in some cases. Definitely talk to your doctor about the pair.
- Aspirin. Aspirin is a more powerful blood thinner. Don’t take aspirin and serrapeptase together.
- Clopidogrel, Warfarin, and other prescription blood thinners. Same as above — if you’re on any type of blood thinner, don’t add serrapeptase.
In short: Keep serrapeptase and anything that thins your blood separate from one another. When your blood gets too thin, it has trouble clotting. Bleeding can get out of control, and you can develop spontaneous bruises or nosebleeds. Keep in mind, this isn’t medical advice; talk to a physician if you have any questions or concerns about taking serrapeptase.
Serrapeptase dosage, source, and how to take
How much serrapeptase should you take?
You may see the label on serrapeptase supplements in milligrams (mg), serrapeptase units (SPU), or enzymatic units (EU). The conversion is usually 2000 SPU/EU per mg, and the serrapeptase dosage below is based on the one most studies use.
Serrapeptase dose: 10-60 mg (20,000-120,000 SPU/EU), taken two to three times daily (for 30-180 mg total per day)
When to take serrapeptase: On an empty stomach, 30 minutes before a meal or two hours after a meal
Serrapeptase can help you recover from injuries and control inflammation, and it’s just the tip of the iceberg when it comes to the benefits of enzymes like serrapeptase to perform better.
You can use enzymes to get more micronutrients from your food, improve digestion, increase your metabolism, speed up workout recovery, and more.
Check out this Bulletproof Radio podcast episode for a comprehensive discussion about different enzymes and what they do for you.
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